Scientists Developed a New Technique to Reduce the Side Effects of Chemotherapy

General Knowledge » Current Affairs »

Scientists developed a New Technique to reduce the Side Effects of Chemotherapy

Scientists developed a new technique to reduce the Harmful Side Effects of Chemotherapy. The new technique blocks an oxygen – sensitive enzyme and streamlines the blood flow by combining the specific PHD2 Inhibitors with the chemotherapy. Inhibiting PHD2 results in the production of anti – oxidant enzymes were able to neutralise the harmful side effects of chemotherapy. The better formed blood vessels ensure that the anti – cancer drugs are distributed throughout the tumour, which increases their impact.

In Chemotherapy, anti – cancer drugs are not easily delivered to the actual tumour because leaking blood vessels prevent anti – cancer drugs from reaching tumour cells while promoting metastasis. Moreover, chemotherapy can adversely affect healthy organs, resulting into heart and kidney failure.

LONDON : Scientists claim to have developed a new technique which dramatically reduces the harmful side effects of chemotherapy by blocking an oxygen – sensitive enzyme and streamlining the blood flow. Researchers from VIB / KU Leuven, Belgium have found that chemotherapy combined with specific PHD2 inhibitors would make it more effective while reducing the harmful side effects.

General Studies Question Bank CD

Researchers Statement :

The effectiveness of chemotherapy is limited by the difficulties of delivering the anti – cancer drugs to the actual tumour, researchers said in a statement. Tumours are characterised by abnormally shaped blood vessels — they are irregular in shape, have weak textures and easily tear.

These leaking blood vessels prevent anti – cancer drugs from reaching tumour cells while promoting metastasis. Secondly, chemotherapy can have seriously harmful effects on healthy organs, leading even to heart and kidney failure. Earlier research had already shown that reduced activity of the oxygen sensor PHD2 under hypoxic conditions resulted in a more streamlined vasculature.

In the new study, Rodrigo Leite de Oliveira, Sofie Deschoemaker and Max Mazzone used mouse models to prove their earlier hypothesis that streamlining blood flow by inhibiting PHD2 can render cancer treatments more effective.

Firstly, the better formed blood vessels ensure that the anti – cancer drugs are distributed throughout the tumour, thus increasing their impact.

They also allow for smaller doses – a significant advantage when administering toxic drugs. The researchers further proved that inhibiting PHD2 results in the production of anti – oxidant enzymes were able to neutralise the harmful side effects of chemotherapy.

The researchers further proved that inhibiting PHD2 results in the production of anti — oxidant enzymes were able to neutralise the harmful side effects of chemotherapy.

JEE Main

Application Form Submission 16 Dec 2020 to 16 Jan 2021.